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High Prevalence of a Hotspot of Noncoding Somatic Mutations in Intron 6 of GPR126 in Bladder Cancer.
Garinet S, Pignot G, Vacher S, Le Goux C, Schnitzler A, Chemlali W, Sirab N, Barry Delongchamps N, Zerbib M, Sibony M, Allory Y, Damotte D, Bieche I. Garinet S, et al. Mol Cancer Res. 2019 Feb;17(2):469-475. doi: 10.1158/1541-7786.MCR-18-0363. Epub 2018 Nov 6. Mol Cancer Res. 2019. PMID: 30401719
A recent study revealed a mutational hotspot in intron 6 of GPR126 gene in 2.7% of a large breast cancer series. As GPR126 is highly expressed in bladder tissues, we investigated here the prevalence and the prognostic significance of these mutations in …
A recent study revealed a mutational hotspot in intron 6 of GPR126 gene in 2.7% of a large breast cancer series. As GPR126 …
Development of a Sensitive Digital Droplet PCR Screening Assay for the Detection of GPR126 Non-Coding Mutations in Bladder Cancer Urine Liquid Biopsies.
Jain M, Tivtikyan A, Kamalov D, Avdonin S, Rakhmatullin T, Pisarev E, Zvereva M, Samokhodskaya L, Kamalov A. Jain M, et al. Biomedicines. 2023 Feb 8;11(2):495. doi: 10.3390/biomedicines11020495. Biomedicines. 2023. PMID: 36831030 Free PMC article.
Recent whole-genome sequencing studies identified two novel recurrent mutations in the enhancer region of GPR126 in urothelial bladder cancer (UBC) tumor samples. This mutational hotspot is the second most common after the TERT promoter in UBC. ...The simulta …
Recent whole-genome sequencing studies identified two novel recurrent mutations in the enhancer region of GPR126 in urothelial bla …
Genomic Instability Signature of Palindromic Non-Coding Somatic Mutations in Bladder Cancer.
Vacher S, Suybeng V, Girard E, Masliah Planchon J, Thomson G, Le Goux C, Garinet S, Schnitzler A, Chemlali W, Firlej V, Damotte D, Allory Y, Kamal M, Pignot G, Bieche I. Vacher S, et al. Cancers (Basel). 2020 Oct 8;12(10):2882. doi: 10.3390/cancers12102882. Cancers (Basel). 2020. PMID: 33049910 Free PMC article.
The goal of this study was to identify clinical biomarkers in non-coding regions for bladder cancer patients. We have previously identified in bladder tumors two non-coding mutational hotspots occurring at high frequencies (30%). ...We identified a new type o …
The goal of this study was to identify clinical biomarkers in non-coding regions for bladder cancer patients. We have previous …
Gpr126 (Adgrg6) is expressed in cell types known to be exposed to mechanical stimuli.
Musa G, Cazorla-Vázquez S, van Amerongen MJ, Stemmler MP, Eckstein M, Hartmann A, Braun T, Brabletz T, Engel FB. Musa G, et al. Ann N Y Acad Sci. 2019 Nov;1456(1):96-108. doi: 10.1111/nyas.14135. Epub 2019 Jun 19. Ann N Y Acad Sci. 2019. PMID: 31215653
Moreover, GPR126 (ADGRG6) mutations are associated with human diseases, like adolescent idiopathic scoliosis, lung disease, bladder cancer, and intellectual disability. ...In addition, we provide data with cellular resolution for previously described RT-PCR-b …
Moreover, GPR126 (ADGRG6) mutations are associated with human diseases, like adolescent idiopathic scoliosis, lung disease, bladde …
Regulatory region mutations of TERT, PLEKHS1 and GPR126 genes as urinary biomarkers in upper tract urothelial carcinomas.
Xing X, Yuan X, Liu T, Dai M, Fan Y, Liu C, Strååt K, Björkholm M, Xu D. Xing X, et al. J Cancer. 2021 May 5;12(13):3853-3861. doi: 10.7150/jca.56779. eCollection 2021. J Cancer. 2021. PMID: 34093793 Free PMC article.
Background: The hotspot regulatory region mutations of the TERT, PLEKHS1 and GPR126 genes have been shown to occur frequently in urothelial bladder carcinoma (UBC). ...Conclusions: This proof-of-concept study demonstrates that the hotspot mutations in the TERT, PLEK …
Background: The hotspot regulatory region mutations of the TERT, PLEKHS1 and GPR126 genes have been shown to occur frequently in urot …